Do nonspecific symptoms have you
questioning the diagnosis?

It could be HLH

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome characterized by a rapidly progressive state of maladaptive hyperinflammation. It presents with a range of nonspecific signs and symptoms of multisystem distress that can overlap with other conditions, making the diagnostic process difficult.1 Find out how to identify this dangerous immune dysregulation in your patients before it’s too late.

HLH patient graphic with symptoms

MULTISYSTEM DISTRESS1

MULTISYSTEM DISTRESS1

Persistent high fever icon

Persistent high fever

Central nervous system involvement icon

Central nervous system involvement

Rash icon

Rash

Hyperferritinemia, hepatosplenomegaly, and hypertriglyceridemia icon

Hyperferritinemia
Hepatosplenomegaly
Hypertriglyceridemia

Cytopenia icon

Cytopenias

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome characterized by a rapidly progressive state of maladaptive hyperinflammation. It presents with a range of nonspecific signs and symptoms of multisystem distress that can overlap with other conditions, making the diagnostic process difficult.1 Find out how to identify this dangerous immune dysregulation in your patients before it’s too late.

HLH macrophage icon

Pathophysiology of HLH

Learn about the mechanisms of immune dysregulation in HLH.

What happens in HLH?
HLH patient icon

Signs and Symptoms

See how HLH can manifest in patients.

Learn the signs
HLH diagnostic checklist icon

Diagnosing HLH

Explore the diagnostic process for HLH.

How to diagnose HLH

Reference: 1. Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011;118(15):4041-4052. doi:10.1182/blood-2011-03-278127